PIRCHE is a digital diagnostics company dedicated to improving the treatment and quality of life of patients with life threatening illnesses. Our patented epitope matching technology models the indirect pathway of T-cell mediated allorecognition of mismatched HLA to estimate the risk of adverse immune responses following solid organ and stem cell transplantation (SOT and HSCT). This allows for risk stratification and monitoring of patients pre and post transplant and for the best available HLA mismatched donors to be found.